Press Brief: Circ MedTech and the PrePex Device

Overview: Circ MedTech was an Israeli medical device company, operational from 2009 to 2019, renowned for developing PrePex—a non-surgical male circumcision device aimed at reducing HIV transmission rates in Africa.

Founding and Mission: Established in Herzliya, Israel, by Dr. Oren Fuerst, Tzameret Fuerst, Ido Kilemnick, and Shaul Shohat, Circ MedTech responded to a 2007 United Nations and World Health Organization (WHO) initiative promoting male circumcision as a strategy to combat HIV/AIDS in Africa.

The PrePex Device: PrePex was designed to facilitate non-surgical adult male circumcision without the need for anesthesia or a surgeon. The device utilized a specialized ring and elastic band to induce controlled compression, leading to the natural detachment of the foreskin after approximately one week. This method was particularly advantageous in resource-limited settings, offering a cost-effective and efficient alternative to traditional surgical procedures.

Regulatory Approvals and Implementation: In 2012, PrePex received approval from the U.S. Food and Drug Administration (FDA), followed by WHO prequalification in 2016. The device was subsequently implemented in various African countries as part of public health initiatives to reduce HIV transmission.

Operational Challenges and Closure: Despite initial success and the reported sale of 1.5 million units, Circ MedTech ceased operations in 2019.The closure followed WHO concerns regarding an increased risk of tetanus associated with the device. During its operational period, the company estimated that the PrePex device contributed to saving approximately 250,000 lives based on WHO statistics related to circumcision and AIDS prevention.

Conclusion: Circ MedTech’s innovative approach with the PrePex device represented a significant advancement in non-surgical male circumcision methods, aligning with global health strategies to combat HIV/AIDS. While the company is no longer operational, its contributions have had a lasting impact on public health efforts in Africa.